DAY 3: Tuesday, September 23, 2025

07:00 - 17:00

Registration Open

07:15 - 08:15

Industry-Sponsored Symposia with Breakfast

ISSX Sponsors

• Wuxi AppTec

• BioIVT

08:30 - 09:30

Plenary Lecture 2

Taking an HBV oligo into Ph3 - Reflections from the ADME team

• Steve Hood, GSK, UK

09:30 - 10:00

Break, Posters, Exhibitors

Thought Leader Presentation

• Discovery Life Sciences: 09:40 - 09:50

10:00 - 12:00

Concurrent Symposia 5 & 6

Symposium 5: Challenges with Targeted Genetic Medicines: Exploring the New Frontiers of Oligonucleotide Therapeutics

Co-chairs: Everett Perkins, Eli Lilly, USA; Asami Toshima, Kyowa Kirin Co., Ltd., Japan

• What are optimal PK and PK/PD properties for single and double stranded oligos?
  Ben-Filippo Krippendorff, Pierre Fabre Group, France

• Intracellular and in Vivo Disposition of Fab– siRNA Conjugates
  Asami Toshima, Kyowa Kirin Co, Japan

• Exploring metabolic clearance of siRNAs
  Chris Wiethoff, Lilly, USA

• RNAi based therapeutics and novel RNA Bioengineering technologies
  Ai-Ming Yu, Univ California, Davis, USA

Symposium 6: Impact of Artificial Intelligence & Machine Learning in Drug Discovery & Development

Co-chairs: James Lu, A*STAR Bioinformatics Institute, Singapore, and Andreas Reichel, Bayer, Germany

• Machine-Learning Frameworks to Predict the Pharmacokinetic Profile of Small Molecule Drugs
  Nikhil Pillai, Sanofi, USA

• Explainable ML Workflow for Exposure-Response Relations: Applications to Small and Large Molecule Drugs
  James Lu, A*STAR Bioinformatics Institute, Singapore

• The Impact of Protein Large Language Models in Drug Discovery & Development
  Chris Langmead, Amgen, USA

• Enchant: A Multi-Modal Transformer Model to Break Down the Data Wall between Preclinical and Clinical Research and Development
  Tom Miller, Iambic Therapeutics, USA

12:00 - 14:30

Lunch/Exhibits/Poster Viewing/Thought Leader Presentations

Poster Session 2 Presentations, P46-P126
12:30 - 13:30: Odd Poster Presentations
13:30 - 14:30: Even Poster Presentations

Thought Leader Presentation Schedule
Charles River: 12:45 - 12:55
SCIEX: 13:00 - 13:10
WuXi AppTec: 13:15 - 13:25

14:30 - 16:00

2025 Awards

• The R.T. Williams Distinguished Scientific Achievement Award

• The Frederick J. Di Carlo Distinguished Service Award,

• Distinguished Accomplishments in Drug Discovery and Development Award

16:00 - 17:15

Best Poster Presentations