Monday, September 12, 2022

Program subject to change.

7:00 am - 8:15 am | New Investigators Networking Session

Elliott Bay

All investigators within their first ten years of receiving their highest earned degree are welcome to attend and participate in this session. The forum, hosted by the ISSX New Investigators Group, begins with continental breakfast, followed by round table discussions lead by researchers in academia, industry, and government.

8:30 am - 9:30 am | Plenary Lecture 1

Grand Ballroom III - Cytochrome P450/Redox Partner Interactions
Emily Scott, University of Michigan, Ann Arbor, Michigan, USA

9:30 am - 10:00 am | Refreshment Break with Posters and Exhibitors

10:00 am - 12:00 pm | Concurrent Symposia 1 and 2

Grand Ballroom III - Symposium 1: Advances in in silico ADME and Structure-based Modeling Prediction
Chairs: Christopher Keefer, Pfizer, Groton, Connecticut, USA and Emily Scott, University of Michigan, Ann Arbor, Michigan, USA

Comparison of Mechanistic and Machine Learning Based Human PK Prediction
Christopher Keefer, Pfizer, Groton, Connecticut, USA

In silico ADME Science: A constant Evolution Toward Fueling Human-focused Learning Cycles During Drug Discovery
Prashant Desai, Genentech Indianapolis, Indiana, USA

In vitro and in silico Based Optimization of Drug Half-life
Fabio Brocatelli, Bristol Meyers Squibb, La Jolla, California, USA

Structure of CYP8B1 with a Rationally Designed CYP8B1 Inhibitor: Providing Directions for Inhibitor Optimizations
Jinghan Liu, University of Michigan, Ann Arbor, Michigan, USA

Cascade I&II - Symposium 2: Organization of P450 System and Related Proteins in Biological Membranes
Chairs: Wayne L. Backes, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA, and Yuji Ishii, Kyushu University, Fukuoka, Japan

Functional Interactions between CYP3A4 and UDP-glucuronosyltransferases: A Crucial Role of Luminal Domain of UGT
Yuji Ishii, Kyushu University, Fukuoka, Japan

Heme Oxygenase-1 affects Cytochrome P450 Function through the Formation of Protein-protein Complexes
Wayne Backes, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

Assembling the P450 Puzzle: Impact of P450-P450 Interactions on the Pathways of Drug Metabolism
Dmitri Davydov, Washington State University, Pullman, Washington, USA

Protein/Protein Interaction in the Human Cytochrome P450 System
Sarah D. Burris-Hiday, University of Michigan, Ann Arbor, Michigan, USA

12:00 pm - 3:00 pm | Exhibits and Posters

Grand Ballroom I&II

Grand Foyer - Poster Awards Competition Finalist Poster Presentations Posters A1-A12

Fifth Avenue Room - Poster Viewing Posters P1-P195

3:00 pm - 5:00 pm | Concurrent Symposia 3 and 4

Grand Ballroom III - Symposium 3: Cryo-EM to Advance Functional and Mechanistic Insights of Enzymes and Transporters
Chair: Yoichi Osawa, University of Michigan, Ann Arbor, Michigan, USA

Cryo-EM Structures of ATP- and Substrate-bound States of MRP4
Deanna Kroetz, UCSF, San Francisco, San Francisco, California, USA

Tetrameric Complex of Cytochrome P450 CYP2B4 and NADPH-Cytochrome P450 Reductase Revealed by Transmission Electron Microscopy
Haoming Zhang, The University of Michigan Medical School, Ann Arbor, Michigan, USA

Structural and Functional Insights into a Peroxisomal Fatty-acid Transporter
Meghna Gupta, University of San Francisco California, San Francisco, California, USA

Cascade I&II - Symposium 4: 3-D culture, Organ-on-chip, and Microphysical Systems in ADME Studies
Chairs: Baitang Ning, National Center for Toxicological Research of the U.S. FDA, Jefferson, Arkansas, USA and Nina Isoherranen, University of Washington, Seattle, Washington, USA

Next Generation in vitro Models for ADME: Do More Complex MPS Models More Accurately Predict in vivo Outcome?
Tom Chan, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA

The Use of an in vivo 3D Human Liver Spheroid System for Prediction of Drug-induced Enzyme Expression, Drug Pharmacokinetics and Drug Hepatotoxicity
Magnus Ingelman-Sundberg, Karolinska Institute, Solna, Sweden

Microphysical Systems in Drug Development and Precision Medicine
Tomoki Imaoka, Daiichi Sankyo Co., Ltd, Tokyo, Japan

The Development of Novel in vitro Systems of the Human Intestine to Predict Oral Drug Disposition
Christopher Arian, University of Washington, Seattle, Washington, USA

5:00 pm - 5:15 pm | Break

5:15 pm - 5:30 pm | A Tribute to Michael Waterman

Grand Ballroom III

5:30 pm - 6:30 pm | ISSX Awards Presentations

Grand Ballroom III - 2022 Award for Outstanding Achievement in Xenobiotic Research by a Scientist from an Underrepresented Nation
Sponsored by Pfizer

Award to be presented to Nancy Hakooz, Ph.D. and Award Lecture, "Same, same but DIFFERENT", My Journey of Drug Metabolism Research in Jordan,  to follow

Grand Ballroom III - 2022 Frederick J. Di Carlo Distinguished Service Award

Award to be presented to Bill J. Smith, Ph.D. and Award Lecture, Professional Growth through ISSX service – My Journey, to follow

7:00 pm - 9:00 pm | Poster Viewing

Grand Foyer and Fifth Avenue Room