Tuesday, September 13, 2022
Program subject to change.
7:15 am - 8:15 am | Concurrent Industry-Sponsored Symposia with Breakfast
Grand Ballroom III - BioIVT Industry-Sponsored Symposium: The Role of Liver-humanized Mice in the Drug Development Toolkit
Sean Nygaard, Yecuris Corporation
Cascade I&II - Eurofins Discovery Industry-Sponsored Symposium: Comprehensive in vitro Approach to Evaluating Transporter-mediated Drug Interactions in Drug Discovery
Yong Zhao, Eurofins Discovery
8:30 am - 9:30 am | Plenary Lecture 2
Grand Ballroom III - What Drugs Do to Our Bugs
Kiran Patil, University of Cambridge, Cambridge, UK
9:30 am - 10:00 am | Refreshment Break with Posters and Exhibitors
Grand Ballroom I&II
10:00 am - 12:00 pm | Concurrent Symposia 5 and 6
Grand Ballroom III - Symposium 5: Clinical Development Impact Stories of Microdosing and Microtracer Studies
Chairs: Marie Croft, Pharmaron ABS, Inc, Germantown, Maryland, USA and Graeme Young, GSK, Ware, Hertfordshire, United Kingdom
Microtracer and AMS-enabled Study Designs in Clinical Development: Applications, Challenges and Opportunities
Marie Croft, Radiolabeled Sciences, Pharmaron ABS, Inc, Germantown, Maryland, USA
The AMS-enabled Human Absorption, Distribution, Metabolism & Excretion (hADME) Study: A Technological and Strategic Paradigm Shift
Douglas Spracklin, Pfizer, Groton, Connecticut , USA
Microdosing and Microtracer Studies in Pediatrics: An Innovative Approach to Study Drug Disposition in this Vulnerable Population
Bianca van Groen, Roche, Basel, Switzerland
Paradigm Shift(s) to the Human ADME Strategy, Enabled by AMS - Output from a Cross-industry Consortia
Graeme Young, GSK, Ware, Herfordshire, United Kingdom
Cascade I&II - Symposium 6: Role of Non-coding RNAs in Xenobiotic Metabolism and Regulation
Chairs: David J. Waxman, Boston University, Boston, Massachusetts, USA and Kyounghyun Kim, University of Cincinnati, Cincinnati, Ohio, USA
Widespread Dysregulation of lncRNAs in Xenobiotic-exposed Liver: Single Cell Approaches to Elucidate lncRNA Function
David J. Waxman, Boston University, Boston, Massachusetts, USA
LncRNAs HNF1A-AS1 and HNF4A-AS1 in Drug Metabolism and Drug-induced Toxicity
Lirong Zhang, Zhengzhou University, Zhengzhou, Henan, China
NR2E3 is a Key Component in p53 Activation by Regulating a Long Noncoding RNA DINO in Acute Liver Injuries
Kyounghyun Kim, University of Arkansas Medical Sciences, Fayetteville, Arkansas, USA
RNA Adventures in Metabolic Control
Tamer Sallam, University of California, Los Angeles, CA, USA
12:00 pm - 2:30 pm | Exhibits and Posters
Grand Ballroom I&II
Fifth Avenue Room Poster Presentations P1-P103
Grand Foyer Poster Award Finalist Poster Viewing
2:30 pm - 3:30 pm | ISSX Poster Award Finalist Competition Podium Presentations
Grand Ballroom III
3:30 pm - 4:30 pm | ISSX Awards Presentations
Grand Ballroom III - 2022 R.T. Williams Distinguished Scientific Achievement Award and Lecture
Award to be presented to Magnus Ingelman-Sundberg, Ph.D. and Award Lecture, From CYP2C12 to CYP2C19 during 50 years of P450 Research, to follow
Grand Ballroom III - 2022 Distinguished Accomplishments in Drug Discovery and Development Award and Lecture
Award to be presented to Dennis A. Smith, Ph.D. and Award Lecture to follow
4:30 pm - 5:45 pm | Plenary Session
Grand Ballroom III - Advancement and Influencers in the Prediction of Drug Interactions and Human Exposure
Chairs: Jaydeep Yadav, Merck, Boston, Massachusetts, USA and Katrina Claw, University of Colorado, Aurora, Colorado, USA
Therapeutic Protein DDI and it's Clinical Relevance
Qin Sun, US-FDA, Silver Spring, Maryland, USA
Gene-drug Interactions and Variation in Indigenous Populations
Katrina Claw, University of Colorado, Aurora, Colorado, USA
siRNA mediated DDI: Challenges and Opportunities
Armina Abbasi, Amgen Inc., South San Francisco, California, USA
5:45 pm - 9:00 pm | Poster Viewing
Grand Foyer and Fifth Avenue Room
6:00 pm - 8:00 pm | Networking Reception at the Seattle Art Museum
Sponsored by Discovery Life Sciences and Takeda
All attendees are invited to attend this special event at the Seattle Art Museum! Enjoy refreshments and the company of fellow attendees as you explore the exhibits and collections.