Wednesday, June 14, 2023

Program subject to change.

08:30 -09:30 | Plenary Lecture 3 | Weston Auditorium

ADME Tactics in the Discovery/Development of Oral COVID-19 Protease Inhibitors
Amit S. Kalgutkar, Pfizer, Inc

09:30 - 10:00 | Refreshment Break with Posters and Exhibitors | Cricket Hall Sports Village

10:00 - 11:00 | Early Careers Abstract Presentations | Weston Auditorium

Chairs: Jamie Henshall, UCB New Medicines, Slough, United Kingdom and Ana Alfirevic, University of Liverpool, Liverpool, United Kingdom

11:00 - 12:00 | Poster Presentations | Weston Auditorium

Chairs: Jamie Henshall, UCB New Medicines, Slough, United Kingdom and Ana Alfirevic, University of Liverpool, Liverpool, United Kingdom

Poster Finalist Presentations
Poster Award Presentations

12:00 - 13:00 | Exhibit Hall Hours and Poster Viewing | Cricket Hall Sports Village

12:15 - 12:30 | SOLVO Biotechnology - A Charles River Company Showcase | N002

Transporter Assays – DDI and Beyond

Noémi Szili, Ph.D., SOLVO Biotechnology - A Charles River Company

13:00 - 15:00 | Plenary Session 4 | Weston Auditorium

Microphysiological Systems for ADME Applications
Chairs: Carmen Pin, AstraZeneca, Cambridge, United Kingdom

Microphysiological systems aim mimic the physiological environment and function of human organs in vitro, offering a promising alternative to traditional cell culture and animal models in ADME and safety applications. This session will discuss the examples of the progress, challenges and future potential in application of microphysiological systems with a focus of GI as an exemplar.

Digital Twins and Organ-on-chips. The Key to Humanizing Drug Discovery?
Christian Maass, esqLABS GmbH, Saterland, Germany

GI Organoid Models for Safety
Carrie Duckworth, University of Liverpool, Liverpool, United Kingdom

Mathematical Modeling of Drug Exposure in GI Organoid Models
Carmen Pin, AstraZeneca, Cambridge, United Kingdom

15:00 - 15:30 | Refreshment Break | Cricket Hall Sports Village

15:30 - 17:00 | Plenary Session 5 | Weston Auditorium

War Stories: Drug Discovery from the Trenches
Chairs: Amit Kalgutkar, Pfizer and Simone Schadt, F. Hoffmann La Roche, Ltd.

The Story of Risdiplam: From Concept to a First-in-class Oral Small-molecule mRNA Splicing Modifier
Agnes Poirer, F. Hoffman La Roche, Ltd., Basel, Switzerland

Translational PKPD: Battles Won but the Fight Goes on
James Yates, GSK, Stevenage, United Kingdom

Predicting human PK to Wave hADME?
Patrick Schweigler, Novartis