Thursday, June 15, 2023

Program subject to change.

4th DMDG European Biotransformation Workshop

The purpose of this workshop is to provide a platform for biotransformation scientists to discuss topics of interest to them and the biotransformation community at large. Building on the success and interest European Biotransformation Workshops, this is our 4th meeting. The full agenda is below and all times are in BST (British Summer Time).

08:30-08:45 | WELCOME: Presentation of chairs, agenda, meeting logistics
Axel Pähler (Roche), Emre Isin (Servier), Marie Ahlqvist (AstraZeneca), Markus Walles (Novartis)

08:45 -10:30 | SESSION 1: Unusual Biotransformation Reactions
Chair: Markus Walles, Novartis

08:45-09:30 Presentation 1: Unusual Biotransformation reactions
Emre Isin, Servier

09:30-10:00 Presentation 2: Seeing is Believing?
Axel Pähler, Roche

10:00-10:30 Discussion

10:30-10:45 | COFFEE BREAK

10:45-12:00 | SESSION 2: Software aided identification of small molecule and peptide metabolites
Chair: Marie Ahlqvist, AstraZeneca

10:45-11:10 Presentation 3: Evolving Strategies for Software-Assisted Data Interrogation of Small-Molecule Biotransformation Studies
Daniel Weston, GSK

11:10-11:35 Presentation 4: Biotransformation software for peptides metabolite identification
Ismael Zamora, Lead Molecular Design

11:35-12:00 Discussion

12:00-13:00 | NETWORKING LUNCH/COFFEE

13:00-15:00 | SESSION 3: New Label and Label Free Methods to Generate Metabolite Profiles in Drug Development
Chair: Axel Pähler, Roche

13:00-13:30 Presentation 5: The use of 14C labeled substrates to trace endogenous metabolite pathways via AMS
Wouter Vaes, TNO

13:30-14:00 Presentation 6: The use of quantitative NMR in mass balance and metabolite profiling studies, and regulatory perspectives
Alexander David James, Novartis

14:00-14:30 Presentation 7: Metabolite profiling of peptide-DOTA conjugates
Petra Kern, Novartis

14:30-15:00 Discussion

15:00-15:30 | WORKSHOP CLOSURE

The cost to attend the workshop includes the following: